/* =================================================================
   Remimazolam TCI Simulator (Eleveld 2025) — main.css
   Clinical dark theme. Mobile-first, PWA-friendly.
   ================================================================= */

:root {
  /* surfaces */
  --bg: #0D1117;
  --bg-elev: #161B22;
  --bg-elev-2: #1C2330;
  --border: #2A3441;
  --border-strong: #3A4A5C;

  /* text */
  --text: #C9D1D9;
  --text-dim: #8B98A5;
  --text-faint: #5B6776;

  /* brand / accents */
  --primary: #5BA4CF;
  --primary-dim: #2C5870;
  --success: #2EA88B;
  --warning: #D4A017;
  --danger: #E2603B;

  /* chart series */
  --c-cp: #3A8FD6;       /* remimazolam plasma */
  --c-ce-bis: #2EA88B;   /* effect-site (BIS) */
  --c-ce-moaas: #9B72B0; /* effect-site (MOAA/S) */
  --c-met: #D4A017;      /* CNS7054 metabolite */
  --c-bis: #E2603B;      /* predicted BIS */
  --c-moaas: #C77DCE;    /* MOAA/S */
  --c-target: #E2603B;   /* target line */

  --radius: 12px;
  --radius-sm: 8px;
  --gap: 14px;
  --font: 'Figtree', -apple-system, BlinkMacSystemFont, 'Segoe UI', 'Helvetica Neue',
          'Hiragino Sans', 'Noto Sans JP', sans-serif;
  --mono: 'SF Mono', 'JetBrains Mono', 'Roboto Mono', ui-monospace, monospace;
}

* { box-sizing: border-box; margin: 0; padding: 0; }

html { -webkit-text-size-adjust: 100%; }

body {
  font-family: var(--font);
  background: var(--bg);
  color: var(--text);
  font-size: 16px;
  line-height: 1.5;
  min-height: 100vh;
  padding-bottom: env(safe-area-inset-bottom);
  -webkit-font-smoothing: antialiased;
}

/* ---------------- Header ---------------- */
.app-header {
  position: sticky; top: 0; z-index: 40;
  background: linear-gradient(180deg, #0D1117 0%, rgba(13,17,23,0.92) 100%);
  backdrop-filter: blur(8px);
  border-bottom: 1px solid var(--border);
  padding: calc(env(safe-area-inset-top) + 10px) 16px 10px;
}
.app-header h1 { font-size: 1.05rem; font-weight: 600; letter-spacing: 0.2px; }
.app-header .sub { font-size: 0.72rem; color: var(--text-dim); margin-top: 1px; }
.patient-summary {
  display: flex; align-items: center; justify-content: space-between;
  margin-top: 10px; gap: 10px;
}
.patient-summary .info { font-size: 0.8rem; color: var(--text-dim); font-family: var(--mono); }
.patient-summary .info b { color: var(--text); font-weight: 600; }

/* ---------------- Layout ---------------- */
.container { max-width: 920px; margin: 0 auto; padding: 16px; }

/* ---------------- Tabs ---------------- */
.tabs {
  display: flex; gap: 4px; background: var(--bg-elev);
  border: 1px solid var(--border); border-radius: var(--radius);
  padding: 4px; margin: 14px 0;
}
.tab {
  flex: 1; text-align: center; padding: 9px 6px; border-radius: var(--radius-sm);
  font-size: 0.8rem; font-weight: 500; color: var(--text-dim);
  background: transparent; border: none; cursor: pointer; transition: all 0.15s;
}
.tab.active { background: var(--primary-dim); color: #fff; }
.tab:disabled { opacity: 0.4; cursor: not-allowed; }

.panel { display: none; }
.panel.active { display: block; animation: fade 0.2s ease; }
@keyframes fade { from { opacity: 0; transform: translateY(4px); } to { opacity: 1; transform: none; } }

/* ---------------- Cards ---------------- */
.card {
  background: var(--bg-elev); border: 1px solid var(--border);
  border-radius: var(--radius); padding: 16px; margin-bottom: var(--gap);
}
.card h2 { font-size: 0.95rem; font-weight: 600; margin-bottom: 12px; color: var(--text); }
.card h3 { font-size: 0.82rem; font-weight: 600; color: var(--text-dim); margin: 8px 0; text-transform: uppercase; letter-spacing: 0.5px; }

/* ---------------- Forms ---------------- */
.field { margin-bottom: 12px; }
.field label { display: block; font-size: 0.78rem; color: var(--text-dim); margin-bottom: 5px; }
.field input[type="text"], .field input[type="number"], .field select {
  width: 100%; padding: 10px 12px; font-size: 16px; font-family: var(--font);
  background: var(--bg); color: var(--text);
  border: 1px solid var(--border-strong); border-radius: var(--radius-sm);
}
.field input:focus, .field select:focus { outline: none; border-color: var(--primary); }

.grid-2 { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; }
.grid-3 { display: grid; grid-template-columns: repeat(3, 1fr); gap: 10px; }
@media (max-width: 560px) { .grid-3 { grid-template-columns: 1fr 1fr; } }

.radio-row { display: flex; gap: 8px; }
.radio-row label {
  flex: 1; text-align: center; padding: 9px; font-size: 0.82rem;
  background: var(--bg); border: 1px solid var(--border-strong);
  border-radius: var(--radius-sm); cursor: pointer; color: var(--text-dim);
}
.radio-row input { display: none; }
.radio-row input:checked + span { color: #fff; }
.radio-row label:has(input:checked) { background: var(--primary-dim); border-color: var(--primary); color: #fff; }

/* ---------------- Stepper ---------------- */
.stepper { display: flex; align-items: center; gap: 8px; }
.stepper button {
  width: 40px; height: 40px; border-radius: var(--radius-sm); font-size: 1.3rem;
  background: var(--bg-elev-2); color: var(--text); border: 1px solid var(--border-strong);
  cursor: pointer; flex-shrink: 0;
}
.stepper button:active { background: var(--primary-dim); }
.stepper input { text-align: center; font-family: var(--mono); font-weight: 600; }

/* ---------------- Buttons ---------------- */
.btn {
  display: inline-flex; align-items: center; justify-content: center; gap: 6px;
  padding: 11px 18px; font-size: 0.88rem; font-weight: 600; font-family: var(--font);
  border-radius: var(--radius-sm); border: 1px solid transparent; cursor: pointer;
  transition: filter 0.15s;
}
.btn:active { filter: brightness(1.15); }
.btn:disabled { opacity: 0.45; cursor: not-allowed; }
.btn-primary { background: var(--primary); color: #06121b; }
.btn-success { background: var(--success); color: #04130f; }
.btn-danger { background: var(--danger); color: #1a0a04; }
.btn-ghost { background: transparent; color: var(--text); border-color: var(--border-strong); }
.btn-block { width: 100%; }
.btn-row { display: flex; gap: 10px; flex-wrap: wrap; }

/* ---------------- Metric readouts ---------------- */
.metrics { display: grid; grid-template-columns: repeat(auto-fit, minmax(120px, 1fr)); gap: 10px; }
.metric {
  background: var(--bg); border: 1px solid var(--border); border-radius: var(--radius-sm);
  padding: 12px; text-align: center;
}
.metric .val { font-family: var(--mono); font-size: 1.5rem; font-weight: 700; }
.metric .unit { font-size: 0.7rem; color: var(--text-faint); }
.metric .lbl { font-size: 0.7rem; color: var(--text-dim); margin-top: 2px; }
.metric.bis .val { color: var(--c-bis); }
.metric.ce .val { color: var(--c-ce-bis); }
.metric.cp .val { color: var(--c-cp); }
.metric.met .val { color: var(--c-met); }
.metric.moaas .val { color: var(--c-moaas); }

/* ---------------- Chart ---------------- */
.chart-wrap { position: relative; height: 320px; margin: 8px 0; }
@media (max-width: 560px) { .chart-wrap { height: 260px; } }
.chart-hint {
  font-size: 0.68rem; color: var(--text-faint); text-align: center;
  margin: -2px 0 8px; user-select: none;
}

/* ---------------- Emergence forecast panel ---------------- */
.recovery {
  background: var(--bg); border: 1px solid var(--border-strong);
  border-radius: var(--radius-sm); padding: 12px 14px; margin: 8px 0 4px;
}
.rec-head {
  display: flex; align-items: baseline; justify-content: space-between;
  gap: 8px; margin-bottom: 10px; flex-wrap: wrap;
}
.rec-title { font-size: 0.82rem; font-weight: 600; color: var(--text); }
.rec-from { font-size: 0.72rem; color: var(--warning); font-family: var(--mono); }
.rec-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 8px; margin-bottom: 8px; }
.rec-cell {
  background: var(--bg-elev); border: 1px solid var(--border);
  border-radius: var(--radius-sm); padding: 9px 11px;
}
.rec-cell.awake { border-left: 3px solid var(--success); }
.rec-cell.wake { border-left: 3px solid var(--primary); }
.rec-lbl { font-size: 0.7rem; color: var(--text-dim); margin-bottom: 4px; }
.rec-cell-sub { color: var(--text-faint); font-family: var(--mono); }
.rec-val { font-family: var(--mono); font-size: 1.25rem; font-weight: 700; color: var(--text); }
.rec-cell .rec-val { font-size: 1.25rem; }
.rec-val.unreachable { font-size: 0.85rem; font-weight: 600; color: var(--text-faint); }

/* recorded ROC input */
.rec-roc {
  display: flex; flex-direction: column; gap: 3px;
  padding: 8px 0; border-top: 1px solid var(--border);
}
.rec-roc .rec-ctrl { font-size: 0.78rem; color: var(--text); }
.rec-roc input[type="number"] {
  width: 82px; padding: 5px 8px; font-size: 0.9rem; font-family: var(--mono);
  background: var(--bg-elev); color: var(--text);
  border: 1px solid var(--border-strong); border-radius: 6px;
}
.rec-roc-src {
  display: none; font-size: 0.66rem; color: var(--warning);
  font-family: var(--font); font-style: italic;
}
.rec-roc-src.shown { display: inline; }

/* secondary (PK decrement) row */
.rec-row {
  display: flex; align-items: center; justify-content: space-between;
  gap: 12px; padding: 8px 0 0; border-top: 1px solid var(--border);
}
.rec-secondary .rec-val { font-size: 0.95rem; font-weight: 600; color: var(--text-dim); }
.rec-ctrl-wrap { display: flex; flex-direction: column; gap: 4px; flex: 1; min-width: 0; }
.rec-ctrl-lbl { font-size: 0.72rem; color: var(--text-dim); }
.rec-muted { color: var(--text-faint); }
.rec-sub { font-size: 0.68rem; color: var(--text-faint); font-family: var(--mono); }
.rec-ctrl { display: flex; align-items: center; gap: 8px; min-width: 0; }
.rec-chips { display: inline-flex; gap: 6px; }
.rec-chip {
  padding: 3px 10px; font-size: 0.74rem; font-family: var(--mono);
  background: var(--bg-elev); color: var(--text-dim);
  border: 1px solid var(--border-strong); border-radius: 999px; cursor: pointer;
}
.rec-chip.active { background: var(--primary-dim); color: #fff; border-color: var(--primary); }
.rec-row .rec-val { white-space: nowrap; }
@media (max-width: 560px) { .rec-grid { grid-template-columns: 1fr; } }

/* ---------------- Info (ⓘ) icon + popover ---------------- */
.info-ico {
  display: inline-flex; align-items: center; justify-content: center;
  cursor: pointer; color: var(--primary); opacity: 0.85;
  font-size: 0.9em; line-height: 1; user-select: none;
}
.info-ico:hover { opacity: 1; }
.info-ico:focus-visible { outline: 2px solid var(--primary); outline-offset: 2px; border-radius: 3px; }
.info-popup {
  position: absolute; z-index: 300; max-width: min(360px, 92vw);
  background: var(--bg-elev); color: var(--text);
  border: 1px solid var(--border-strong); border-radius: var(--radius-sm);
  padding: 12px 14px; box-shadow: 0 12px 34px rgba(0,0,0,0.55);
  font-size: 0.78rem; line-height: 1.5;
}
.info-popup[hidden] { display: none; }
.info-popup h4 { font-size: 0.86rem; margin-bottom: 6px; color: var(--text); }
.info-popup h5 {
  font-size: 0.68rem; text-transform: uppercase; letter-spacing: 0.4px;
  color: var(--text-dim); margin: 9px 0 3px;
}
.info-popup p { margin: 4px 0; color: var(--text-dim); }
.info-popup ul { margin: 3px 0 4px 16px; color: var(--text-dim); }
.info-popup li { margin: 2px 0; }
.info-popup a { color: var(--primary); }
.info-popup b { color: var(--text); }
.info-popup .ip-cite { font-size: 0.72rem; color: var(--text-faint); }
.info-popup .ip-links { font-family: var(--mono); font-size: 0.72rem; }
.info-popup .ip-params { font-family: var(--mono); }
.info-popup .ip-warn {
  color: #e9cf86; border-top: 1px solid var(--border);
  padding-top: 7px; margin-top: 9px;
}

/* ---------------- Table ---------------- */
.tbl { width: 100%; border-collapse: collapse; font-size: 0.8rem; font-family: var(--mono); }
.tbl th, .tbl td { padding: 7px 8px; text-align: right; border-bottom: 1px solid var(--border); }
.tbl th { color: var(--text-dim); font-weight: 600; text-align: right; }
.tbl td:first-child, .tbl th:first-child { text-align: left; }
.tbl-wrap { max-height: 340px; overflow-y: auto; }

/* ---------------- Notice / banners ---------------- */
.notice {
  font-size: 0.78rem; padding: 10px 12px; border-radius: var(--radius-sm);
  border: 1px solid var(--border-strong); background: var(--bg); margin: 10px 0;
}
.notice.warn { border-color: var(--warning); color: #e9cf86; background: rgba(212,160,23,0.08); }
.notice.danger { border-color: var(--danger); color: #f0a78d; background: rgba(226,96,59,0.08); }
.notice.info { border-color: var(--primary-dim); color: #a7cfe6; }

/* ---------------- Modal ---------------- */
.modal-backdrop {
  position: fixed; inset: 0; background: rgba(0,0,0,0.6); z-index: 100;
  display: none; align-items: flex-start; justify-content: center; padding: 24px 16px;
  overflow-y: auto;
}
.modal-backdrop.open { display: flex; }
.modal {
  background: var(--bg-elev); border: 1px solid var(--border-strong);
  border-radius: var(--radius); width: 100%; max-width: 480px; padding: 20px;
  margin-top: env(safe-area-inset-top);
}
.modal h2 { margin-bottom: 14px; }
.modal-footer { display: flex; gap: 10px; margin-top: 16px; }

/* ---------------- Footer ---------------- */
.app-footer {
  text-align: center; font-size: 0.7rem; color: var(--text-faint);
  padding: 24px 16px; line-height: 1.7;
}
.app-footer a { color: var(--text-dim); }

.hidden { display: none !important; }
.update-banner {
  position: fixed; bottom: 16px; left: 50%; transform: translateX(-50%);
  background: var(--primary); color: #06121b; padding: 10px 16px;
  border-radius: var(--radius-sm); font-size: 0.8rem; font-weight: 600; z-index: 200;
  box-shadow: 0 6px 20px rgba(0,0,0,0.4);
}